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Last Updated 05/01/08

Comparison of Propofol and Fospropofol Pharmacokinetics

To reference this educational web simulation according to the APA style for Web references, use:

Lampotang S, Lizdas D, Gravenstein N, Yavas S (2006):  Web Simulation of Fospropofol Pharmacokinetics.  Retrieved <insert date of retrieval here>, from University of Florida Department of Anesthesiology Virtual Anesthesia Machine Web site: http://vam.anest.ufl.edu/

Please visit and contribute to our Wiki page on fospropofol pharmacokinetics (PK).

Propofol and Fospropofol Comparison

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This interactive simulation of PK for fospropofol is based on a 5-compartment model from Fechner et al, Anesthesiology 99:303-13, 2003. Two compartments are used to model fospropofol PK and three compartments for propofol PK, including a slow peripheral compartment.  Propofol administered alone can also be modeled simultaneously. Users can select either the Fechner (default) or the Gepts model for propofol. Users can adjust the following variables and visualize the essential effects of their interventions on fospropofol and propofol concentration in any of the 5 compartments: weight, infusion rate,infusion duration, dose of initial and second bolus dose and timing of second bolus.

The first 5 variables can be adjusted either by the slider bars or by placing the cursor in the desired number field and manually entering numbers from the keyboard. To adjust the timing of the second bolus of propofol or fospropofol, click and drag the syringe icon representing the second bolus. Plot parameters are also user-adjustable.  The range of time durations represented on the X axis can be 20 min, 1 hr, 6 hrs, 24 hrs and 48 hrs. The concentration values on the Y axis can be plotted on a linear scale or a log 10 scale.  The Y-axis autoscale feature can be toggled off and the Y scale manually adjusted, if desired.

By default, only the concentrations in both propofol central compartments are plotted.  To plot concentration in other compartments, click on the “Plot” button in the compartments.  For sedation, the default values of the user adjustable lower (ROC – recovery of response to verbal command) and upper thresholds (LOC – loss of response to verbal command) are 1.3 and 2.1 mg/L (mcg/ml).

Clicking on the Genetic Polymorphism button generates different plots simulating the variability between individual patients.  The simulation, once configured to the desired settings, can be saved by clicking on the “Link to this simulation and settings” icon.  This will modify the URL in the address bar.  Cut and paste that modified URL into email, documents, Powerpoint files or web pages so that the simulation initializes at the desired settings.