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Last Updated 12/10/14

Simulation of Propofol Pharmacokinetics

To reference this educational web simulation according to the APA style for Web references, use:

Lampotang S, Lizdas D, Gravenstein N, Yavas S (2006):  Web Simulation of Propofol Pharmacokinetics. Retrieved < insert date of retrieval here >, from University of Florida Department of Anesthesiology Virtual Anesthesia Machine Web site: http://vam.anest.ufl.edu/simulations/propofol.html

This interactive simulation of propofol pharmacokinetics is based on a 3-compartment model either from Gepts et al, Anesthesia & Analgesia 66:1256-63, 1987 (default) or Fechner et al, Anesthesiology 99:303-13, 2003. 


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The third compartment is a slow peripheral compartment that is useful when simulating long term propofol administration in an intensive care setting. Users can adjust the following variables and visualize the essential effects of their interventions on propofol concentration in any of the 3 compartments:  weight, infusion rate, infusion duration, dose of initial and second bolus dose and timing of second bolus. The first 5 variables can be adjusted either by the slider bars or by placing the cursor in the desired number field and manually entering numbers from the keyboard. To adjust the timing of the second bolus, click and drag the syringe icon representing the second bolus. Plot parameters are also user-adjustable.  The range of time durations represented on the X axis can be 20 min, 1 hr, 6 hrs, 24 hrs and 48 hrs.  The concentration values on the Y axis can be plotted on a linear scale or a log 10 scale.  The Y-axis autoscale feature can be toggled off and the Y scale manually adjusted, if desired.  By default, only the concentration in the central compartment is plotted.  To plot concentration in other compartments, mouse over the representation of the desired compartment; click on the “Show” button that appears.  Default values of the user adjustable lower and upper thresholds are 1.5 and 5.0 mg/L (mcg/ml), the bounds for the therapeutic range of propofol.  Clicking on the Genetic Polymorphism button generates different plots simulating the variability between individual patients.  The simulation, once configured to the desired settings, can be saved by clicking on the Link to this simulation and settings icon.  This will modify the URL in the address bar.  Cut and paste that modified URL into email, documents, PowerPoint files or web pages so that the simulation initializes at the desired settings.