To do list

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Below are some learning objectives that could be conveyed via SLOs. Please help create these pages using descriptive page titles. Thank you.

Using the 2 compartment deterministic simulation

A constant FRACTION is eliminated per unit time in a first order PK model independent of dose

RATE of elimination proportional to dose in first order system

Time to reach a plateau dependent only on Kel in a first order system

It takes 5 half lives to get to steady state with a constant infusion rate

Show that the concentration plot for a bolus is the mirror of one for a constant infusion. Adding the two theoretically produces a step input in drug concentration

Doubling the dose does not double the duration of effective drug concentration

The half-time is the time for an initial drug concentration to be halved. There is nothing magic about the fraction half. We could also use 1/3 time or any other fraction.

A drug that is administered slowly at the maintenance rate takes a long time to reach steady state.

Using the 1-compartment stochastic simulation

The simple dynamics that create an exponential function

Simulation portfolio - http://vam.anest.ufl.edu/wip.html